Promise of the Genomic Revolution: Hearing Before a Subcommittee of the Committee on Appropriations, United States Senate, One Hundred Seventh Congress, First Session, Special Hearing, July 11, 2001, Washington, DC.U.S. Government Printing Office, 2002 - 49 lappuses |
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A-T Children's Project able advances Affleck Alzheimer's Ben Affleck beta-secretase billion biology BRARY cause Celebrex Celera Chairman children with A-T chromosome clinical research clinical trials colon cancer committee CONG CONGRES CONGRESS THE LIBRARY cox2 cure database Diabetes Genetics Consortium discovery disorders DNA sequence efforts families Francis Collins funding genetic information genetic risk Genome Research GENOMIC REVOLUTION going GRESS hearing Human Genome Project human genome sequence important Institute interact kids kinase genes KINDREGAN LIBRA LIBRARY OF CONGRESS Margus medicine mice molecular mouse mutation Needleman netic NHGRI ONGRES patients percent Pharmacia pharmacogenomics physicians potential prevention promise protein RARY RESS risk of type scientific scientists Senator HARKIN Senator LANDRIEU Senator STEVENS Single Nucleotide Polymorphism STATEMENT stem cells studies subcommittee technologies Thank therapy tion treatment tumors type 1 diabetes understanding Wake Forest University
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5. lappuse - To wrest from nature the secrets which have perplexed philosophers in all ages, to track to their sources the causes of disease, to correlate the vast stores of knowledge, that they may be quickly available for the prevention and cure of disease — these are our ambitions.
8. lappuse - Genetic discrimination is unfair to workers and their families. It is unjustified — among other reasons, because it involves little more than medical speculation. A genetic predisposition toward cancer or heart disease does not mean the condition will develop. To deny employment or insurance to a healthy person based only on a predisposition violates our country's belief in equal treatment and individual merit.
19. lappuse - Earth, the world in which we live." ("Phaedo" by Plato, EP Button & Co.) Socrates could hardly have understood how prophetic his statement of 2400 years ago was, for it has only been in the last few years that we have been able to rise above our atmosphere and fully appreciate the power of observing our own Earth from that vantage point.
6. lappuse - ... unevenly distributed across the genomic landscape; they are crowded in some regions and spread out widely in others. — Individual human genes are commonly able to produce several different proteins. — More than 200 human genes arrived to the genome of some ancestor directly from bacteria. — The repetitive DNA sequences that make up much of our genome, and commonly regarded as "junk," have been important for evolutionary flexibility, allowing genes to be shuffled and new ones to be created....
6. lappuse - Project scientists and computational experts oegan to scour the sequence for insights. They reported the first key discoveries in the February 15, 2001 issue of the journal Nature. Among the findings were the following: — Humans are likely to have only 30,000 to 35,000 genes, just twice as many as a fruit fly, and far fewer than the 80,000 to 150,000 that had been widely predicted. — Genes are unevenly distributed across the genomic landscape; they are crowded in some regions and spread out widely...
7. lappuse - ... profiles, since drugs that are effective in some people are less effective in others and, in some, cause severe side effects. These differences in drug response are largely genetically determined. Customizing medicine to a patient's likely response is a promising new field known as pharmacogenomics. A recent publication in the journal Hypertension showed how pharmacogenomics applies to high blood pressure. Researchers found a variation in a particular gene that affects how patients respond to...
6. lappuse - FY 2002, NHGRI will increase the usefulness of the human genome sequence to the world's researchers by finishing the sequencing to match the project's long-standing goals for completeness and stringent accuracy. More than a third of the draft sequence already has been finished into a highly accurate form - containing no more than 1 error per 10,000 bases. Finished sequence for the entire genome is expected by 2003. Finished sequence is already available for the entire lengths of chromosomes 21 and...
20. lappuse - Of patients between the ages of 20 and 74, diabetic retinopathy is the leading cause of new cases of blindness in the United States.
44. lappuse - Directory of Residency Training Programs Accredited by the Accreditation Council for Graduate Medical Education. Chicago: American Medical Association, 1981— . Annual.
20. lappuse - Diabetes now accounts for almost 40 percent of aJl new cases of end-stage renal disease in the United States, and persons with diabetes make up the fastest growing group of renal dialysis and transplant recipients.