Principles and Practices of Method ValidationA Fajgelj, A Ambrus Royal Society of Chemistry, 2007. gada 31. okt. - 314 lappuses Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a large number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information. |
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The Potential Use of Quality Control Data to Validate Pesticide Residue Method Performance | 1 |
Optimization and Evaluation of Multiresidue Methods for Priority Pesticides in Drinking and Related Waters | 9 |
Validation of Analytical Data in a Research and Development Environment | 19 |
Performance Validation of a Multiresidue Method for 170 Pesticides in Kiwifruit | 29 |
Effects of Sample Processing on Pesticide Residues in Fruit and Vegetables | 41 |
Testing the Efficiency and Uncertainty of Sample Processing Using 14CLabelled Chlorpyrifos Part I Description of the Methodology | 49 |
Testing the Efficiency and Uncertainty of Sample Processing Using 14CLabelled Chlorpyrifos Part II | 59 |
Testing the Effect of Sample Processing and Storage on the Stability of Residues | 75 |
Validation of a Multiresidue Method for Analysis of Pesticides in Fruit Vegetables and Cereals by a GCMS Iontrap System | 108 |
Development and Validation of a Generic Gas Chromatographic Method for the Determination of Organophosphorus Pesticide Residues in Various S... | 120 |
Validation of Gas Chromatographic Databases for Qualitative Identification of Active Ingredients of Pesticide Residues | 128 |
Estimation of Significance of Matrixinduced Chromatographic Effects | 138 |
Worked Example for Validation of a Multiresidue Method | 157 |
EU Guidance Documents on Residue Analytical Methods | 176 |
Guidelines for SingleLaboratory Validation of Analytical Methods for Tracelevel Concentrations of Organic Chemicals | 179 |
A Critique on Available InHouse Method Validation Documentation | 253 |
AOAC International Collaborative Study on the Determination of Pesticide Residues in Nonfatty Foods by Supercritical Fluid Extraction and Gas Chr... | 89 |
Validation of Analytical Methods Proving Your Method is Fit for Purpose | 100 |
Citi izdevumi - Skatīt visu
Principles and Practices of Method Validation Aleš Fajgelj,Árpád Ambrus Ierobežota priekšskatīšana - 2000 |
Bieži izmantoti vārdi un frāzes
acceptable Ambrus analysis analyte concentration analytical methods analytical portions analytical standards AOAC AOAC International apple applied average recovery Azinphos-methyl blank samples calculated calibration levels calibration points chemical Chlorothalonil chlorpyrifos chopper chromatographic Codex Alimentarius Codex Level coefficient collaborative study column compounds criteria detector determined Diazinon Dimethoate Endosulfan estimated ethyl acetate extraction fortification level fortified gas chromatographic GC/MS Guidelines homogeneity homogenisation injection Iprodione isooctane kiwifruit lettuce limit of detection Lindane linear matrix effect matrix equivalent measured Methamidophos method performance method validation mg/kg multi-residue obtained parameters peak performance characteristics Permethrin pesticide residues precision procedure proficiency testing Propargite protocol quantitative range reference material regression relative standard deviation replicate reported representative analytes response retention sample processing selected solvent specific spiked stability t-test Table temperature test portion tomato trueness typical uncertainty of sample values variance veterinary drug vinclozolin