Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
|
No grāmatas satura
1.5. rezultāts no 83.
5. lappuse
... reduced muscle mass and a decline in creatinine synthesis rate. For example, creatinine synthesis rate may be substantially reduced in elderly patients, so it is not unusual for serum creatinine concentrations to remain within normal ...
... reduced muscle mass and a decline in creatinine synthesis rate. For example, creatinine synthesis rate may be substantially reduced in elderly patients, so it is not unusual for serum creatinine concentrations to remain within normal ...
12. lappuse
... reduced the incidence of toxic reactions to this drug (7). The traditional digoxin serum level recommendations were based largely on studies in which digoxin toxicity or intermediate inotropic endpoints were measured, and the challenge ...
... reduced the incidence of toxic reactions to this drug (7). The traditional digoxin serum level recommendations were based largely on studies in which digoxin toxicity or intermediate inotropic endpoints were measured, and the challenge ...
28. lappuse
... reduced in animals whose spleen and lower intestine had been removed (15). Indirect evidence also has been provided by a study of the distribution and pharmacologic effects of insulin, a compound with molecular weight and extracellular ...
... reduced in animals whose spleen and lower intestine had been removed (15). Indirect evidence also has been provided by a study of the distribution and pharmacologic effects of insulin, a compound with molecular weight and extracellular ...
44. lappuse
... reduced by the fractional drug disposition that occurs between q and t[H(t − q)], that is: X(t)= ∫ t 0 G(q)· H(t − q)dq The function H(t) describes drug disposition after intravenous bolus administration of a unit dose at time t. The ...
... reduced by the fractional drug disposition that occurs between q and t[H(t − q)], that is: X(t)= ∫ t 0 G(q)· H(t − q)dq The function H(t) describes drug disposition after intravenous bolus administration of a unit dose at time t. The ...
51. lappuse
... reduced by half. Three days later, the patient was noted to be confused. An initial diagnosis of dialysis dementia was made and the family was informed that dialysis would be discontinued. On teaching rounds, the suggestion was made ...
... reduced by half. Three days later, the patient was noted to be confused. An initial diagnosis of dialysis dementia was made and the family was informed that dialysis would be discontinued. On teaching rounds, the suggestion was made ...
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
339. lappuse - There are. however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed Nursing Mothers: It is not known whether this drug is excreted in human milk.
403. lappuse - Any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer.
285. lappuse - Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).
285. lappuse - The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute.
223. lappuse - P (1994). Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the bloodbrain barrier and to increased sensitivity to drugs. Cell, 77: 491-502.
268. lappuse - Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin. Pharmacol. Ther.
7. lappuse - Pratt WB, Taylor P, eds. Principles of drug action: The basis of pharmacology. 3rd ed.
285. lappuse - Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2: Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context.
Atsauces uz šo grāmatu
Bioequivalence and Statistics in Clinical Pharmacology Scott D. Patterson,Byron Jones Ierobežota priekšskatīšana - 2005 |
Pharmaceutical Biotechnology: Fundamentals and Applications, Third Edition Daan J. A. Crommelin,Robert D. Sindelar,Bernd Meibohm Priekšskatījums nav pieejams - 2007 |