Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
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No grāmatas satura
1.–5. rezultāts no 27.
x. lappuse
... Pregnancy 344 Results of Selected Pharmacokinetic Studies in Pregnant Women 344 Guidelines for the Conduct of Drug Studies in Pregnant Women 347 Placental Transfer of Drugs 348 Teratogenesis 349 Principles of Teratology 350 Measures to ...
... Pregnancy 344 Results of Selected Pharmacokinetic Studies in Pregnant Women 344 Guidelines for the Conduct of Drug Studies in Pregnant Women 347 Placental Transfer of Drugs 348 Teratogenesis 349 Principles of Teratology 350 Measures to ...
30. lappuse
... pregnancy alters the elimination kinetics of many drugs. But physiological 5.0 1.0 0.4 0.2 0.1 changes in body fluid compartment volumes and protein binding also affect drug distribution in pregnant subjects. As discussed in Chapter 22 ...
... pregnancy alters the elimination kinetics of many drugs. But physiological 5.0 1.0 0.4 0.2 0.1 changes in body fluid compartment volumes and protein binding also affect drug distribution in pregnant subjects. As discussed in Chapter 22 ...
35. lappuse
... pregnancy. Clin Pharmacol Ther 1986;40:321–8. 5. Øie S, Tozer TN. Effect of altered plasma protein binding on apparent volume of distribution. J Pharm Sci 1979;68:1203–5. 6. Lombardo F, Shalaeva MY, Tupper KA, Gao F. ElogDoct: A tool ...
... pregnancy. Clin Pharmacol Ther 1986;40:321–8. 5. Øie S, Tozer TN. Effect of altered plasma protein binding on apparent volume of distribution. J Pharm Sci 1979;68:1203–5. 6. Lombardo F, Shalaeva MY, Tupper KA, Gao F. ElogDoct: A tool ...
149. lappuse
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
161. lappuse
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
339. lappuse - There are. however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed Nursing Mothers: It is not known whether this drug is excreted in human milk.
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