Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
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No grāmatas satura
1.–5. rezultāts no 91.
vi. lappuse
... Parameters 90 Kinetics and the Link to Mathematics 90 Pharmacokinetic Parameters 91 Noncompartmental Analysis 92 Noncompartmental Model 92 Kinetic Parameters of the vi Contents.
... Parameters 90 Kinetics and the Link to Mathematics 90 Pharmacokinetic Parameters 91 Noncompartmental Analysis 92 Noncompartmental Model 92 Kinetic Parameters of the vi Contents.
vii. lappuse
... Parameters of the Noncompartmental Model 93 Estimating the Kinetic Parameters of the Noncompartmental Model 95 Compartmental Analysis 97 Definitions and Assumptions 97 Linear, Constant-Coefficient Compartmental Models 99 Parameters ...
... Parameters of the Noncompartmental Model 93 Estimating the Kinetic Parameters of the Noncompartmental Model 95 Compartmental Analysis 97 Definitions and Assumptions 97 Linear, Constant-Coefficient Compartmental Models 99 Parameters ...
ix. lappuse
... Parameters 293 Dose Effect and Site of Drug Action 294 Quantal Dose-Effect Relationship 295 Therapeutic Indices 296 Dose Effect and Defining Optimal Dose 297 Pharmacodynamic Models 298 Fixed-Effect Model 298 Maximum-Effect (Emax and ...
... Parameters 293 Dose Effect and Site of Drug Action 294 Quantal Dose-Effect Relationship 295 Therapeutic Indices 296 Dose Effect and Defining Optimal Dose 297 Pharmacodynamic Models 298 Fixed-Effect Model 298 Maximum-Effect (Emax and ...
xii. lappuse
... Parameters 465 Use of Allometry in Designing Intraperitoneal Dose Regimens 465 Physiological Pharmacokinetics 467 In Vitro–in Vivo Correlation of Hepatic Metabolism 469 CHAPTER. 31. Phase I Clinical Studies JERRY M. COLLINS Introduction ...
... Parameters 465 Use of Allometry in Designing Intraperitoneal Dose Regimens 465 Physiological Pharmacokinetics 467 In Vitro–in Vivo Correlation of Hepatic Metabolism 469 CHAPTER. 31. Phase I Clinical Studies JERRY M. COLLINS Introduction ...
13. lappuse
... parameters of distribution volume and elimination clearance that characterize it. Initiation of Drug Therapy (Concept of Apparent Distribution Volume) Sometimes. Dose V d CLE FIGURE 2.4 Diagram of a single-compartment model in which the ...
... parameters of distribution volume and elimination clearance that characterize it. Initiation of Drug Therapy (Concept of Apparent Distribution Volume) Sometimes. Dose V d CLE FIGURE 2.4 Diagram of a single-compartment model in which the ...
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
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