Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
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No grāmatas satura
1.–5. rezultāts no 34.
40. lappuse
... organic nitrates, propranolol, lidocaine, and cyclosporine are some commonly used drugs that have extensive first-pass metabolism or intestinal P-glycoprotein transport. As a result, effective oral doses of these drugs are substantially ...
... organic nitrates, propranolol, lidocaine, and cyclosporine are some commonly used drugs that have extensive first-pass metabolism or intestinal P-glycoprotein transport. As a result, effective oral doses of these drugs are substantially ...
53. lappuse
... organic anion transporters have been identified (16). Transporters involved in drug secretion are located both at the basolateral membrane of renal tubule cells, where they transport drugs from blood into these cells, and at the ...
... organic anion transporters have been identified (16). Transporters involved in drug secretion are located both at the basolateral membrane of renal tubule cells, where they transport drugs from blood into these cells, and at the ...
55. lappuse
... organic molecules that accumulate in uremia. As described in Chapter 3, reductions in the protein binding of acidic drugs result in increases in their distribution volume. In addition, the elimination clearance of restrictively ...
... organic molecules that accumulate in uremia. As described in Chapter 3, reductions in the protein binding of acidic drugs result in increases in their distribution volume. In addition, the elimination clearance of restrictively ...
57. lappuse
... Organic anion transporters and organic cation transporters. J Pharm Sci 2001;90:397–421. Liegler DG, Henderson ES, Hahn MA, Oliverio VT. The effect of organic acids on renal clearance of methotrexate in man. Clin Pharmacol Ther 1969;10 ...
... Organic anion transporters and organic cation transporters. J Pharm Sci 2001;90:397–421. Liegler DG, Henderson ES, Hahn MA, Oliverio VT. The effect of organic acids on renal clearance of methotrexate in man. Clin Pharmacol Ther 1969;10 ...
146. lappuse
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
Esat sasniedzis šīs grāmatas aplūkošanas reižu limitu.
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
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