Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
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No grāmatas satura
1.–5. rezultāts no 91.
v. lappuse
... Kinetics 17 Mathematical Basis of Clinical Pharmacokinetics 18 First-Order Elimination Kinetics 18 Concept of Elimination Half-Life 19 Relationship of k to Elimination Clearance 19 Cumulation Factor 19 Plateau Principle 20 Application ...
... Kinetics 17 Mathematical Basis of Clinical Pharmacokinetics 18 First-Order Elimination Kinetics 18 Concept of Elimination Half-Life 19 Relationship of k to Elimination Clearance 19 Cumulation Factor 19 Plateau Principle 20 Application ...
vi. lappuse
... Kinetics Of Intermittent Hemodialysis 59 Solute Transfer across Dialyzing Membranes 59 Calculation of Dialysis Clearance 61 Patient Factors Affecting Hemodialysis of Drugs 62 Kinetics of Continuous Renal Replacement Therapy 65 Clearance ...
... Kinetics Of Intermittent Hemodialysis 59 Solute Transfer across Dialyzing Membranes 59 Calculation of Dialysis Clearance 61 Patient Factors Affecting Hemodialysis of Drugs 62 Kinetics of Continuous Renal Replacement Therapy 65 Clearance ...
vii. lappuse
... Kinetic Parameters of the Noncompartmental Model 93 Estimating the Kinetic Parameters of the Noncompartmental Model 95 ... Kinetics PAUL F. MORRISON Introduction 107 Central Issues 107 Drug Modality I: Delivery across a Planar–Tissue ...
... Kinetic Parameters of the Noncompartmental Model 93 Estimating the Kinetic Parameters of the Noncompartmental Model 95 ... Kinetics PAUL F. MORRISON Introduction 107 Central Issues 107 Drug Modality I: Delivery across a Planar–Tissue ...
2. lappuse
... kinetics to measure the absolute bioavailability of digoxin and characterize the time course of its chronotropic effects (7), and the founding of Clinical Pharmacology and Therapeutics. Few drugs have focused as much public attention on ...
... kinetics to measure the absolute bioavailability of digoxin and characterize the time course of its chronotropic effects (7), and the founding of Clinical Pharmacology and Therapeutics. Few drugs have focused as much public attention on ...
15. lappuse
... kinetic equilibrium with the intravascular space. The distribution phase of these drugs represents their somewhat ... kinetics is that a constant fraction of total body drug stores will be eliminated in a given time interval. Thus, if ...
... kinetic equilibrium with the intravascular space. The distribution phase of these drugs represents their somewhat ... kinetics is that a constant fraction of total body drug stores will be eliminated in a given time interval. Thus, if ...
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
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