Principles of Clinical PharmacologyArthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey Elsevier, 2011. gada 28. apr. - 568 lappuses This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
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No grāmatas satura
1.–5. rezultāts no 92.
vi. lappuse
... Absorption and Bioavailability ARTHUR J. ATKINSON, JR. Drug Absorption 37 Bioavailability 40 Absolute Bioavailability 41 Relative Bioavailability 42 In Vitro Prediction of Bioavailability 43 Kinetics of Drug Absorption after Oral ...
... Absorption and Bioavailability ARTHUR J. ATKINSON, JR. Drug Absorption 37 Bioavailability 40 Absolute Bioavailability 41 Relative Bioavailability 42 In Vitro Prediction of Bioavailability 43 Kinetics of Drug Absorption after Oral ...
vii. lappuse
... Absorption and Emission Spectroscopy 165 Immunoaffinity Assays 166 Mass Spectrometry 167 Examples of Current Assay Methods 170 HPLC/UV and HPLC/MS Assay of New Chemical Entities — Nucleoside Drugs 170 HPLC/MS/MS Quantitative Assays of ...
... Absorption and Emission Spectroscopy 165 Immunoaffinity Assays 166 Mass Spectrometry 167 Examples of Current Assay Methods 170 HPLC/UV and HPLC/MS Assay of New Chemical Entities — Nucleoside Drugs 170 HPLC/MS/MS Quantitative Assays of ...
viii. lappuse
... Absorption 183 Drug Distribution 183 Drug Elimination 183 Mutations That Influence Drug Receptors 190 Combined Variants in Drug Metabolism and Receptor Genes: Value of Drug Pathway Analysis 191 Conclusions and Future Directions 191 ...
... Absorption 183 Drug Distribution 183 Drug Elimination 183 Mutations That Influence Drug Receptors 190 Combined Variants in Drug Metabolism and Receptor Genes: Value of Drug Pathway Analysis 191 Conclusions and Future Directions 191 ...
ix. lappuse
... between Men and Women MAYLEE CHEN, JOSEPH S. BERTINO, JR., MARY J. BERG, AND ANNE N. NAFZIGER Pharmacokinetics 325 Absorption 326 Distribution 326 Renal Excretion 327 Sex Differences in Metabolic Pathways Contents ix.
... between Men and Women MAYLEE CHEN, JOSEPH S. BERTINO, JR., MARY J. BERG, AND ANNE N. NAFZIGER Pharmacokinetics 325 Absorption 326 Distribution 326 Renal Excretion 327 Sex Differences in Metabolic Pathways Contents ix.
x. lappuse
... Absorption 362 Drug Distribution 363 Drug Metabolism 364 Renal Excretion 365 Therapeutic Implications of Growth and Development 366 Effect on Pharmacokinetics 367 Effect on Pharmacodynamics 370 Effect of Childhood Diseases 370 ...
... Absorption 362 Drug Distribution 363 Drug Metabolism 364 Renal Excretion 365 Therapeutic Implications of Growth and Development 366 Effect on Pharmacokinetics 367 Effect on Pharmacodynamics 370 Effect of Childhood Diseases 370 ...
Saturs
1 | |
9 | |
DRUG METABOLISM AND TRANSPORT | 141 |
ASSESSMENT OF DRUG EFFECTS | 273 |
OPTIMIZING AND EVALUATING PATIENT THERAPHY | 323 |
DRUG DISCOVERY AND DEVELOPMENT | 421 |
APPENDIX I Abbreviated Tables of Laplace Transforms | 527 |
APPENDIX II Answers to Study Problems | 529 |
Index | 537 |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Arthur J. Atkinson Ierobežota priekšskatīšana - 2001 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
absorption acid activity addition administration adverse agents analysis approach binding blood body cancer cause cells changes Chapter clearance Clin Pharmacol Ther clinical compartment compounds concentration decrease described determined differences digoxin disease distribution dose drug development effect elimination enzyme Equation errors estimate et al evaluation example expression factor Figure flow function gene half-life hepatic human identified important increased individuals infusion inhibition inhibitors initial interactions kinetics levels liver measured mechanism medication metabolism metabolites methods molecular needed normal observed occur oral organic P-glycoprotein parameters patients pharmacokinetics pharmacology Phase plasma population potential predicted pregnancy protein reactions receptor reduced relationship relative renal reported response result risk selection shown specific studies substrate Table therapeutic therapy tion tissue toxicity transport treated treatment trials tumor volume women
Populāri fragmenti
339. lappuse - There are. however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed Nursing Mothers: It is not known whether this drug is excreted in human milk.
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223. lappuse - P (1994). Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the bloodbrain barrier and to increased sensitivity to drugs. Cell, 77: 491-502.
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7. lappuse - Pratt WB, Taylor P, eds. Principles of drug action: The basis of pharmacology. 3rd ed.
285. lappuse - Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2: Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context.
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