Principles of Clinical Pharmacology

Pirmais vāks
Arthur J. Atkinson, Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey
Elsevier, 2011. gada 28. apr. - 568 lappuses
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
  • Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
  • Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course
  • Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
  • Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry
  • Expanded coverage of pharmacogenetics
  • Expanded coverage of drug transporters and their role in interactions
  • Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
  • A new chapter on drug discovery that focuses on oncologic agents
  • Inclusion of therapeutic antibodies in chapter on biotechnology products

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CHAPTER 1 Introduction to Clinical Pharmacology
1
PHARMACOKINETICS
9
DRUG METABOLISM AND TRANSPORT
141
ASSESSMENT OF DRUG EFFECTS
273
OPTIMIZING AND EVALUATING PATIENT THERAPHY
323
DRUG DISCOVERY AND DEVELOPMENT
421
APPENDIX I Abbreviated Tables of Laplace Transforms
527
APPENDIX II Answers to Study Problems
529
Index
537
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Par autoru (2011)

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.

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