Principles of Clinical PharmacologyArthur J. Atkinson Jr., Arthur J. Atkinson Gulf Professional Publishing, 2001 - 460 lappuses The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. Key Features * Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy * Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry |
No grāmatas satura
1.–5. rezultāts no 77.
vi. lappuse
... Hepatic Elimination of Drugs 63 Restrictively metabolized Drugs ( ER < 0.3 ) 64 Drugs with an Intermediate Extraction Ratio ( 0.3 < ER < 0.7 ) 65 Nonrestrictively Metabolized Drugs ( ER > 0.70 ) 65 Biliary Excretion of drugs 65 Effects ...
... Hepatic Elimination of Drugs 63 Restrictively metabolized Drugs ( ER < 0.3 ) 64 Drugs with an Intermediate Extraction Ratio ( 0.3 < ER < 0.7 ) 65 Nonrestrictively Metabolized Drugs ( ER > 0.70 ) 65 Biliary Excretion of drugs 65 Effects ...
ix. lappuse
... Hepatic Metabolism 268 Sex Differences in Metabolic Pathways 268 Drug Metabolism Interactions of Particular Importance to Women 269 Renal Excretion 270 Chronopharmacology , Menstrual Cycle , and Menopause 270 Pharmacodynamics 271 ...
... Hepatic Metabolism 268 Sex Differences in Metabolic Pathways 268 Drug Metabolism Interactions of Particular Importance to Women 269 Renal Excretion 270 Chronopharmacology , Menstrual Cycle , and Menopause 270 Pharmacodynamics 271 ...
x. lappuse
... Hepatic and Extrahpatic Drug Biotransformations 310 Age - Related Changes in Effector System Function 311 Central Nervous System ( CNS ) 311 Automatic Nervous System ( ANS ) 312 Cardiovascular Function Renal Function 314 313 Drug Groups ...
... Hepatic and Extrahpatic Drug Biotransformations 310 Age - Related Changes in Effector System Function 311 Central Nervous System ( CNS ) 311 Automatic Nervous System ( ANS ) 312 Cardiovascular Function Renal Function 314 313 Drug Groups ...
xi. lappuse
... Hepatic Metabolism 391 CHAPTER 28 Drug Discovery Introduction 365 ROBERT R. GORMAN The Drug Discovery Process 366 Enabling Technologies 366 High - throughput Screening 366 Combinatorial Chemistry 367 Similarity - Dissimilarity Testing ...
... Hepatic Metabolism 391 CHAPTER 28 Drug Discovery Introduction 365 ROBERT R. GORMAN The Drug Discovery Process 366 Enabling Technologies 366 High - throughput Screening 366 Combinatorial Chemistry 367 Similarity - Dissimilarity Testing ...
33. lappuse
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Saturs
Kinetics of Drug Absorption after Oral 7 | 37 |
ARTHUR J ATKINSON | 43 |
Effects of Renal Disease on Drug Elimination 43 of Liver Cirrhosis | 68 |
CHAPTER | 75 |
Noncompartmental versus Compartmental | 89 |
The Intraperitoneal Administration | 96 |
Summary | 111 |
Conclusions | 118 |
Diseases Progress Models Physiologic Changes During Pregnancy | 280 |
Drug Therapy of Nursing Mothers | 288 |
Drug Therapy in Neonates | 293 |
Effect on Pharmacodynamics | 303 |
AgeRelated Changes in Pharmacokinetics | 309 |
Drug Groups for Which Age Confers Increased Risk | 315 |
26 | 323 |
Quality Assessment of Drug Therapy | 333 |
12 | 126 |
Methods of Analysis of Drugs | 143 |
Examples of Current Assay Methods | 150 |
PART | 157 |
Mechanisms of Drug Interactions 168 Role of Transporters In Pharmacokinetics | 210 |
Transport | 217 |
Teratogenic Reactions to Drugs 197 | 225 |
ELIZABETH S LOWE AND FRANK M BALIS | 235 |
Pharmacodynamic Models 243 Distribution | 267 |
Kinetic Analysis of Pharmacologic Effect Immunology and Immunosuppression 272 Summary | 273 |
Medication Use Evaluation | 345 |
CHAPTER | 351 |
Project Planning and Management Tools 358 In Vivo StudiesPreclinical Toxicology 378 | 360 |
Introduction | 387 |
Drug Discovery | 395 |
Pharmacokinetic and Pharmacodynamic The Drug Action Response Outcome Benefit Paradigm | 424 |
Development | 431 |
Goal and Objectives of Clinical Drug Development | 439 |
447 | |
Citi izdevumi - Skatīt visu
Principles of Clinical Pharmacology Arthur J. Atkinson, Jr.,Darrell R. Abernethy,Charles E. Daniels,Robert Dedrick,Sanford P. Markey Ierobežota priekšskatīšana - 2011 |
Principles of Clinical Pharmacology Arthur J. Atkinson Jr.,Charles E. Daniels,Robert Dedrick,Charles V. Grudzinskas,Sanford P. Markey Priekšskatījums nav pieejams - 2001 |
Bieži izmantoti vārdi un frāzes
accessible pool acid activity administration ADRs adverse drug reactions agents analysis assay Atkinson AJ Jr bioavailability blood flow Cancer cell changes Chapter clearance Clin Pharmacol Ther clinical development CLINICAL PHARMACOLOGY clinical trials compartment compounds creatinine cyclosporine cytochrome cytochrome P450 decreased described digoxin disease distribution volume drug absorption drug concentration drug development drug effect drug interactions drug metabolism elimination enzyme Equation estimate evaluation example excretion factors gene genetic half-life hemodialysis hepatic human increased infusion inhibition inhibitors intestinal intravenous inulin kinetics levels liver macromolecules measured medication errors membrane ment metabolites mL/min molecular molecules normal oral P-gp parameters patients pediatric phar Pharm pharmacodynamic pharmacokinetics pharmacology Phase phenytoin plasma concentrations predicted pregnancy procainamide protein binding receptor renal function renal replacement therapy response result serum specific studies substrate Table target terfenadine theophylline therapeutic therapy tion tissue toxicity transport tumor vitro vivo zidovudine µg/mL
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