Principles of Clinical Pharmacology

Pirmais vāks
Arthur J. Atkinson Jr., Arthur J. Atkinson
Gulf Professional Publishing, 2001 - 460 lappuses
The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

Key Features
* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
* Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course
* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry

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Saturs

Kinetics of Drug Absorption after Oral 7
37
ARTHUR J ATKINSON
43
Effects of Renal Disease on Drug Elimination 43 of Liver Cirrhosis
68
CHAPTER
75
Noncompartmental versus Compartmental
89
The Intraperitoneal Administration
96
Summary
111
Conclusions
118
Diseases Progress Models Physiologic Changes During Pregnancy
280
Drug Therapy of Nursing Mothers
288
Drug Therapy in Neonates
293
Effect on Pharmacodynamics
303
AgeRelated Changes in Pharmacokinetics
309
Drug Groups for Which Age Confers Increased Risk
315
26
323
Quality Assessment of Drug Therapy
333

12
126
Methods of Analysis of Drugs
143
Examples of Current Assay Methods
150
PART
157
Mechanisms of Drug Interactions 168 Role of Transporters In Pharmacokinetics
210
Transport
217
Teratogenic Reactions to Drugs 197
225
ELIZABETH S LOWE AND FRANK M BALIS
235
Pharmacodynamic Models 243 Distribution
267
Kinetic Analysis of Pharmacologic Effect Immunology and Immunosuppression 272 Summary
273
Medication Use Evaluation
345
CHAPTER
351
Project Planning and Management Tools 358 In Vivo StudiesPreclinical Toxicology 378
360
Introduction
387
Drug Discovery
395
Pharmacokinetic and Pharmacodynamic The Drug Action Response Outcome Benefit Paradigm
424
Development
431
Goal and Objectives of Clinical Drug Development
439
Objective 5Differentiation 423 Index
447
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Par autoru (2001)

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.

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