Principles of Clinical Pharmacology

Pirmais vāks
Arthur J. Atkinson, Jr., Charles E. Daniels, Robert Dedrick, Charles V. Grudzinskas, Sanford P. Markey
Gulf Professional Publishing, 2001 - 460 lappuses
The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

Key Features
* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
* Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course
* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry

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Saturs

Invited Reviewers xvii Application of Laplace Transforms
17
PART Distribution Patterns
25
Clinical Pharmacokinetics CHAPTER
31
Initiation of Drug Therapy Concept of Apparent ARTHUR J ATKINSON
48
CHAPTER
75
Noncompartmental versus Compartmental Liver Microsomal Cytochrome P450
126
Introduction 93
143
SANFORD P MARKEY Drug Distribution
161
Analysis of Indirect Pharmacologic Effects 250 Drug Therapy in Pregnant
277
Drug Therapy in Neonates Clinical Detection of ADRS 321 Risk Factors
323
Ontogeny and Pharmacology 296
331
Drug Therapy in the Elderly Formulary Management
337
Medication Use Evaluation
345
CHAPTER
351
Portfolio Design
353
Animal Scaleup
387

Mechanisms of Drug Interactions 168 Role of Transporters In Pharmacokinetics
210
Transport
219
Teratogenic Reactions to Drugs 197
225
Thermodynamics of Membrane Transport 201 Developments
231
ELIZABETH S LOWE AND FRANK M BALIS
235
28
393
Pharmacokinetic and Pharmacodynamic The Drug Action Response Outcome Benefit Paradigm
424
Development
431
Objective 5Differentiation 423 Index
447
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Par autoru (2001)

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.

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