Forensic DNA Typing: Biology & Technology Behind STR MarkersAcademic Press, 2001 - 322 lappuses Forensic DNA Typing focuses on the biology and technology behind short tandem repeat (STR) markers and the most common forensic DNA analysis method used today. This comprehensive handbook will help forensic scientists gain a better understanding of STRs and the procedures needed to properly analyze them, while helping professionals in the law enforcement and legal communities comprehend the complexities of DNA profiling. It will also help laboratories meet the training requirements in the new DNA Advisory Board Quality Assurance Standards. The first few chapters of Forensic DNA Typing provide a thorough introduction to the topic for readers who might be less familiar with DNA, while providing a useful review for more advanced readers. It goes on to cover new genetic markers and information on rapidly changing technologies to help professionals make accurate identifications through DNA typing. Detailed illustrations and examples are used throughout. The book concludes with reviews of the DNA testing performed in high-profile cases such as the O.J. Simpson trial, the President Clinton-Monica Lewinsky affair, the Tomb of the Unknown Soldier, the Thomas Jefferson-Sally Hemings family controversy, and others. John Butler has been involved in the validation of the short tandem repeat markers that form the basis of the FBI's nationwide DNA database, CODIS, and in the development of new and innovative technologies. His talent for explaining complex information is apparent in the clear organization, illustrations, and straightforward language of this text. Forensic DNA Typing has already established itself as the standard reference in the field. Key Benefits: * Chapters cover thetopic from introductory level right up to "cutting edge" research * Forensic scientists learn about the new methods and technologies required by STR typing * DNA laboratories find out how to meet the training requirements of the DNA Advisory Board Quality Assurance Standards (listed in Appendix III) * Lawyers and law enforcement professionals understand the science behind the techniques * All readers can use the information listed on suppliers of DNA analysis equipment, products and services * Provides a comprehensive look at the biology, technology, and applications of DNA typing * Focuses on the major molecular biological technique currently being used throughout the world * Uses a wide array of illustrations and examples to make the material easy to understand * Progresses from basic introductory information to cutting-edge research * Designed for forensic scientists, law enforcement and legal professionals, and students in related fields * Provides DNA analysts with all the reported alleles for the 13 CODIS STR loci, including sizes and sequences * Includes the DNA Advisory Board Quality Assurance Standards * Reviews DNA testing performed in high-profile cases |
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Saturs
OVERVIEW AND HISTORY OF DNA TYPING | 1 |
BIOLOGY | 11 |
DNA BIOLOGY REVIEW | 13 |
SAMPLE COLLECTION AND PREPARATION DNA EXTRACTION AND QUANTIFICATION | 25 |
THE POLYMERASE CHAIN REACTION DNA AMPLIFICATION | 39 |
COMMONLY USED SHORT TANDEM REPEAT MARKERS | 53 |
BIOLOGY OF STRs STUTTER PRODUCTS NONTEMPLATE ADDITION MICROVARIANTS MULL ALLELES AND MUTATION RATES | 81 |
FORENSIC ISSUES DEGRADED DNA PCR INHIBITION CONTAMINATION AND MIXED SAMPLES | 99 |
STR GENOTYPING ISSUES | 191 |
LABORATORY VALIDATION | 205 |
NEW TECHNOLOGIES AND AUTOMATION | 223 |
COMBINED DNA INDEX SYSTEM CODIS AND THE USE OF DNA DATABASES | 239 |
BIOLOGY TECHNOLOGY AND GENETICS | 251 |
DNA TESTING IN HIGHPROFILE CASES | 253 |
REPORTED STR ALLELES SIZES AND SEQUENCES | 273 |
CEPH FAMILY STUDY | 287 |
ADDITIONAL DNA MARKERS AMELOGENIN YCHROMOSOME STRs mtDNA SNPs Alu REPEATS | 117 |
DNA SEPARATION METHODS SLABGEL AND CAPILLARY ELECTROPHORESIS | 135 |
DNA DETECTION METHODS FLUORESCENT DYES AND SILVER STAINING | 147 |
THE ABI PRISM 31O GENETIC ANALYZER | 167 |
THE HITACHI FMBIO II FLUORESCENCE IMAGING SYSTEM | 181 |
DNA ADVISORY BOARD QUALITY ASSURANCE STANDARDS | 289 |
SUPPLIERS OF DNA ANALYSIS EQUIPMENT PRODUCTS OR SERVICES | 305 |
311 | |
Citi izdevumi - Skatīt visu
Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers John M. Butler Ierobežota priekšskatīšana - 2005 |
Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers John Marshall Butler Priekšskatījums nav pieejams - 2005 |
Bieži izmantoti vārdi un frāzes
allele peak allelic ladder amelogenin AmpFISTR analyzed Barber and Parkin biology bp Not published Brinkmann Budowle capillary capillary array capillary electrophoresis cell Chapter chromosome contains convicted offender crime scene detection DNA analysis DNA database DNA fragments DNA markers DNA molecules DNA profiles DNA samples DNA template DNA testing electrophoresis extraction Figure fluorescent dye FMBIO forensic DNA laboratories formamide GenBank genotypes Gill Human Genetics Human Identification injection Journal of Forensic Journal of Legal Kimpton labeled Legal Medicine Lins locus match methods microvariant mixture molecular mtDNA mutation nucleotide null alleles O.J. Simpson Paternity testing PCR amplification PCR products PCR reaction performed Perkin Elmer Corporation polymerase polymerase chain reaction polymorphic PowerPlex primer Promega Promega Corporation region repeat units RFLP short tandem repeat stain STR alleles STR kits STR loci STR markers STR typing strands STRBase stutter product Symposium on Human TCTA thermal cycler TPOX