Principles and Practices of Method Validation

Pirmais vāks
Aleš Fajgelj, Árpád Ambrus
Royal Society of Chemistry, 2000 - 305 lappuses
Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a large number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information.

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Atlasītās lappuses

Saturs

The Potential Use of Quality Control Data to Validate Pesticide Residue
1
Validation of Analytical Data in a Research and Development Environment
19
Effects of Sample Processing on Pesticide Residues in Fruit and Vegetables
41
Testing the Effect of Sample Processing and Storage on the Stability of Residues
75
AOAC International Collaborative Study on the Determination of Pesticide
89
Validation of a Multiresidue Method for Analysis of Pesticides in Fruit
108
Development and Validation of a Generic Gas Chromatographic Method
120
Validation of Gas Chromatographic Databases for Qualitative Identification
128
Estimation of Significance of Matrixinduced Chromatographic Effects
138
Worked Example for Validation of a Multiresidue Method
157
EU Guidance Documents on Residue Analytical Methods
176
A Critique on Available InHouse Method Validation Documentation
253
Subject Index
297
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