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NIST RESEARCH FOR INDUSTRY

Tahndogg

On the Inside

DNA "Fingerprints"
New MTCs
Space Fires

Robotic Humvee
Transparent Ceramics
European Standards
Micromachining
New Products
Co-op Corner

NIST

U.S. DEPARTMENT OF
COMMERCE

Technology Administration

National Institute of
Standards and Technology

October 1992

Dental Process

Fills in Cavities

Chewing gum and toothpaste
that can repair beginning
cavities in teeth soon may be
appearing on drug store and
supermarket shelves thanks to
a patented process developed
by an American Dental As-
sociation research associate
working at NIST.

An exclusive license to use
the process in teeth cleaning

products and chewing gum has

been granted by the American
Dental Association Health
Foundation to Enamelon Inc.
of Yonkers, N.Y. The founda-
tion sponsors a 64-year-old
cooperative research center
with NIST's materials scien-
tists and engineers.

The process involves adding
amorphous calcium phosphate
to standard toothpaste, gel,
powder, or chewing gum. The
amorphous calcium phosphate
is more soluble in the mouth
than other forms of the com-
pound. This allows it to dif-
fuse more easily into tooth
surfaces and form the mineral
hydroxyapatite, the primary
ingredient in teeth and bone.
Preliminary clinical tests have
shown that amorphous cal-
cium phosphate produces
enough remineralization to

desensitize teeth that react
strongly to hot and cold
temperatures. Enamelon plans
to conduct full-scale clinical
testing to verify the desen-
sitization effects and to fully
demonstrate the remineraliza-
tion of cavities. It hopes to
gain approval from the U.S.
Food and Drug Administration
for product sales by 1995.
Contact: Ming Tung,
(301) 975-6823.

"Lens" Focuses
Cold Neutrons

In a joint effort with col

laborators from the Kurchatov
Institute in Moscow, the State
University of New York, and
X-Ray Optical Systems Inc. of
Albany, N.Y., NIST scientists
have demonstrated for the first
time a system for focusing
"cold" neutrons.

The system includes a "lens"
made with many tiny glass
fibers that can focus a beam of
cold (slowed down) neutrons
to a spot the size of the head of
a pin. The ability to focus the
normally difficult-to-steer
neutrons produced by nuclear
research reactors should in-
crease greatly the sensitivity of
tests, such as neutron depth
profiling and prompt gamma
activation analysis, used to

AT A GLANCE

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Standards Kit for
DNA Profiling

A new Standard Reference
Material (SRM) kit issued
by NIST allows forensic and
medical laboratories for the
first time to check the ac-
curacy of their DNA profiling
or "fingerprinting" tech-
niques against a certified set
of standards.

DNA profiles are used with in-
creasing frequency to match
blood, hair, or other samples
found at a crime scene with
samples from murder or rape
suspects. Such analyses are
also used in civil suits to estab-
lish paternity and as DNA
"dog tags" to identify soldiers.
The kit (SRM 2390) contains
separate tubes of carefully
profiled male and female
DNA, as well as about 3 mil-
lion human cells from the
same male and female source
so that the DNA can be ex-
tracted and tested. It also in-
cludes precut fragments of
viral DNA that can be used as
a genetic "ruler" to judge the
size of human DNA fragments
that are the basis for a DNA
"fingerprint."

Laboratories that follow
Federal Bureau of Investiga-
tion protocols can use the
SRM kit to double-check the
accuracy of their analyses at

Tahndogy

AT A GLANCE

NIST is an agency of the US. Department of Commerce's Technology Administration. Its mission is to strengthen U.S. industry's competitiveness, advance science and engineering, and improve public health, safety, and the environment. Technology at a Glance is produced by the Public Affairs Division, A903 Administration Bldg., NIST, Gaithersburg, Md 20899. Any mention of commercial products is for information only, it does not

imply recommendation or endorsement by NIST. Contact: Gail Porter,

(301) 975-3392, with comments or general inquiries.

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each step of the complex DNA profiling process.

Several groups, including the congressional Office of Technology Assessment and the National Academies of Sciences and Engineering, have urged that standards be made available to the forensic and medical communities to help improve quality control of DNA profiling analyses. The 3-year project to develop and certify the SRM was partially funded by the National Institute of Justice.

Contact: Dennis Reeder, (301) 975-3128.

Neutron Lens

continued from previous page aerospace alloys, hightemperature superconductors, high-technology coatings, and other materials. The detector consists of a commercially available video-camera light sensor coated with a neutronsensitive lithium compound.

The lens is made from a bundle of 721 precisely curved lead-silica glass fibers, each

one containing 1,261 hollow glass channels. Each channel is only 6 micrometers in diameter, or about one-tenth the width of a human hair.

The graphic on page 1 depicts the focusing effects of the channels as the detector is moved in 1-centimeter intervals away from the end of the fibers (top to bottom). The green, yellow, orange, and red regions represent greater to lower numbers of neutrons respectively hitting the detector.

Contact: Greg Downing,
(301) 975-6286.

SHORTS

FIRES IN SPACE

NIS researchers have been known to go to great lengths to wadunt ar expensent Now they can say they ve gele ta great heights as we i institute fise tersearchers and Curled jups trun the NASA Lewis Research Center dove and a series of fire text conacted this sucremer on board the space shuttle Colum The tests were desiged to show how riec‡r cai wres burn a longaudy etivt unment. The lack of hunivar for flames interogravity causes differences intame pad and other fire characteristics for those teen of Earth Hi from the project wil help improve fire safety of electrical equi ment for futute Space Baveers Contact Taxshi Kishwig.

A HUMANLESS HUMVEE

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New Products

A new report summarizes the materials science and technology programs of 10 federal agencies, including names and phone numbers for further information. To receive a copy of Advanced Materials and Processing: the Fiscal Year 1993 Program, send a selfaddressed mailing label to: Advanced Materials and

sible applications-tiny tweezers that sense microscopic particles and hold them delivery systems that can be in place for analysis, drug implanted inside the body, or minisensors that detect collisions to trigger air bags in automobiles.

The NIST researchers have used the new technique to design and manufacture arrays of tiny "heaters" that can be used to test and calibrate infrared imaging systems. (See photo below.) Optical ETC of Huntsville, Ala., is cooperating with NIST and plans to incorporate the technology into a commercial product.

The researchers also are working to design micro-sensors for environmental monitoring, real-time control of industrial chemical processing, and highprecision power sensors. Contact: Michael Gaitan, (301) 975-2070.

Processing Program, B309
Materials Bldg., NIST,
Gaithersburg, Md. 20899,
(301) 975-5655.

An upgraded version (4.0) of the NIST/EPA/NIH Mass Spectral Data Base is now available. It includes 62,000 mass spectra for pharmaceuticals, flavors, fragrances, industrial chemicals, and many other compounds. Contact: Standard Reference Data Program, (301) 975-2208.

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Statement of Albert Narath
President, Sandia National Laboratories

U.S. House of Representatives Committee on Small Business Subcommittee on Regulation, Business Opportunities, and Energy December 4, 1992

Exceptional Service in the National Interest

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